Important Safety Information

Last Updated: September 3, 2026

IMPORTANT NOTICE: If you believe you are experiencing a medical emergency, dial 911 or contact your local emergency provider immediately. If you have an erection lasting more than 4 hours, seek emergency medical care right away.

This page summarizes safety information for the prescription erectile dysfunction (ED) medications prescribed through Rodeo Meds, which may contain the PDE5 inhibitors sildenafil, tadalafil, or vardenafil, and may contain apomorphine. It is a summary and not a substitute for the advice of your prescribing clinician or the full prescribing information for your medication. Discuss your complete medical history and every medication and supplement you take with your clinician before starting treatment.

I. Prescription Only

These medications are available by prescription only and are intended for use by adult men diagnosed with erectile dysfunction. They are not for use by women, by anyone under 18, or by anyone for whom they have not been prescribed. Never share your medication.

II. Compounded Medication

Medications prescribed through Rodeo Meds may be compounded. Compounded medications are prepared in FDA-regulated facilities, but the compounded formulations themselves are not FDA-approved and have not been evaluated by the FDA for safety, efficacy, or quality. The decision to prescribe a compounded medication is made by your licensed provider based on your telehealth consultation and medical history. Apomorphine is not FDA-approved for the treatment of erectile dysfunction in the United States.

III. Do Not Take If

You take any medication containing nitrates, in any form, regularly or intermittently. This includes nitroglycerin, isosorbide mononitrate, isosorbide dinitrate, and recreational "poppers" (amyl nitrite or amyl nitrate). Combining a PDE5 inhibitor with nitrates can cause a sudden, dangerous drop in blood pressure.
You take a guanylate cyclase stimulator such as riociguat for pulmonary hypertension.
You have had an allergic reaction to sildenafil, tadalafil, vardenafil, apomorphine, or any ingredient in your prescribed medication.
Your clinician has advised you not to engage in sexual activity because of cardiovascular risk.

IV. Tell Your Clinician About

Heart disease, heart failure, irregular heartbeat, a heart attack or stroke within the last 6 months, unstable angina, or uncontrolled high or low blood pressure.
Any medication for high blood pressure, and any alpha-blocker such as tamsulosin, doxazosin, or alfuzosin. Taken together with a PDE5 inhibitor these can lower your blood pressure further and cause dizziness or fainting.
Liver or kidney disease, including dialysis. Your dose may need to be adjusted.
Sickle cell anemia, multiple myeloma, leukemia, or a deformity of the penis such as Peyronie's disease, all of which raise the risk of a prolonged erection.
Stomach ulcers or a bleeding disorder, retinitis pigmentosa or other inherited eye disease, or prior sudden vision or hearing loss.
Medications that can raise blood levels of PDE5 inhibitors, including ritonavir and other HIV protease inhibitors, ketoconazole, itraconazole, erythromycin, and clarithromycin. Grapefruit and grapefruit juice can have the same effect.
Any other ED treatment. Do not combine ED medications.

V. Serious Risks

Prolonged erection (priapism). An erection lasting more than 4 hours is a medical emergency and can permanently damage the penis if it is not treated. Seek emergency care immediately.
Sudden vision loss. Sudden loss of vision in one or both eyes can be a sign of non-arteritic anterior ischemic optic neuropathy (NAION), a rare condition reported in men taking PDE5 inhibitors. Stop taking the medication and seek medical care immediately.
Sudden hearing loss. Sudden decrease or loss of hearing, sometimes with ringing in the ears or dizziness, has been reported. Stop taking the medication and seek medical care immediately.
Low blood pressure and fainting. Dizziness, lightheadedness or fainting can occur, particularly when standing up, when combined with alpha-blockers, other blood pressure medication, or alcohol. Apomorphine can also cause nausea, vomiting, sweating, and fainting.
Cardiovascular strain. Sexual activity itself carries risk for men with heart disease. Stop and seek medical attention if you develop chest pain, severe shortness of breath, or an irregular heartbeat during sex.
Allergic reaction. Seek emergency care for rash, hives, swelling of the lips, tongue, or throat, or difficulty breathing.

VI. Common Side Effects

The most commonly reported side effects of PDE5 inhibitors are headache, flushing, indigestion, nasal congestion, back pain, muscle aches, dizziness, and changes in vision such as blurring or a blue tinge to colors. Apomorphine may cause nausea, yawning, drowsiness, or sweating. These are not all of the possible side effects. Contact your clinician if a side effect persists or becomes bothersome.

VII. Alcohol and Other Substances

Drinking alcohol while taking these medications can increase the risk of dizziness, low blood pressure, and fainting, and can make ED worse. Do not use recreational nitrates ("poppers") at any time while taking a PDE5 inhibitor.

VIII. Reporting Side Effects

Report side effects to your Rodeo Meds care team, and to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

IX. Contact Information

Modern Metabolic Medicine, Inc.
1811 Silverside Road, Suite 260
Wilmington, New Castle County, Delaware 19180
Email: support@mail.withembody.com

Important Safety Information

Last Updated: September 3, 2026

I. Prescription Only

II. Compounded Medication

III. Do Not Take If

You take any medication containing nitrates, in any form, regularly or intermittently. This includes nitroglycerin, isosorbide mononitrate, isosorbide dinitrate, and recreational "poppers" (amyl nitrite or amyl nitrate). Combining a PDE5 inhibitor with nitrates can cause a sudden, dangerous drop in blood pressure.
You take a guanylate cyclase stimulator such as riociguat for pulmonary hypertension.
You have had an allergic reaction to sildenafil, tadalafil, vardenafil, apomorphine, or any ingredient in your prescribed medication.
Your clinician has advised you not to engage in sexual activity because of cardiovascular risk.

IV. Tell Your Clinician About

Heart disease, heart failure, irregular heartbeat, a heart attack or stroke within the last 6 months, unstable angina, or uncontrolled high or low blood pressure.
Any medication for high blood pressure, and any alpha-blocker such as tamsulosin, doxazosin, or alfuzosin. Taken together with a PDE5 inhibitor these can lower your blood pressure further and cause dizziness or fainting.
Liver or kidney disease, including dialysis. Your dose may need to be adjusted.
Sickle cell anemia, multiple myeloma, leukemia, or a deformity of the penis such as Peyronie's disease, all of which raise the risk of a prolonged erection.
Stomach ulcers or a bleeding disorder, retinitis pigmentosa or other inherited eye disease, or prior sudden vision or hearing loss.
Medications that can raise blood levels of PDE5 inhibitors, including ritonavir and other HIV protease inhibitors, ketoconazole, itraconazole, erythromycin, and clarithromycin. Grapefruit and grapefruit juice can have the same effect.
Any other ED treatment. Do not combine ED medications.

V. Serious Risks

Prolonged erection (priapism). An erection lasting more than 4 hours is a medical emergency and can permanently damage the penis if it is not treated. Seek emergency care immediately.
Sudden vision loss. Sudden loss of vision in one or both eyes can be a sign of non-arteritic anterior ischemic optic neuropathy (NAION), a rare condition reported in men taking PDE5 inhibitors. Stop taking the medication and seek medical care immediately.
Sudden hearing loss. Sudden decrease or loss of hearing, sometimes with ringing in the ears or dizziness, has been reported. Stop taking the medication and seek medical care immediately.
Low blood pressure and fainting. Dizziness, lightheadedness or fainting can occur, particularly when standing up, when combined with alpha-blockers, other blood pressure medication, or alcohol. Apomorphine can also cause nausea, vomiting, sweating, and fainting.
Cardiovascular strain. Sexual activity itself carries risk for men with heart disease. Stop and seek medical attention if you develop chest pain, severe shortness of breath, or an irregular heartbeat during sex.
Allergic reaction. Seek emergency care for rash, hives, swelling of the lips, tongue, or throat, or difficulty breathing.

VI. Common Side Effects

VII. Alcohol and Other Substances

VIII. Reporting Side Effects

Report side effects to your Rodeo Meds care team, and to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

IX. Contact Information

Modern Metabolic Medicine, Inc.
1811 Silverside Road, Suite 260
Wilmington, New Castle County, Delaware 19180
Email: support@mail.withembody.com

Important Safety Information

Last Updated: September 3, 2026

I. Prescription Only

II. Compounded Medication

III. Do Not Take If

You take any medication containing nitrates, in any form, regularly or intermittently. This includes nitroglycerin, isosorbide mononitrate, isosorbide dinitrate, and recreational "poppers" (amyl nitrite or amyl nitrate). Combining a PDE5 inhibitor with nitrates can cause a sudden, dangerous drop in blood pressure.
You take a guanylate cyclase stimulator such as riociguat for pulmonary hypertension.
You have had an allergic reaction to sildenafil, tadalafil, vardenafil, apomorphine, or any ingredient in your prescribed medication.
Your clinician has advised you not to engage in sexual activity because of cardiovascular risk.

IV. Tell Your Clinician About

Heart disease, heart failure, irregular heartbeat, a heart attack or stroke within the last 6 months, unstable angina, or uncontrolled high or low blood pressure.
Any medication for high blood pressure, and any alpha-blocker such as tamsulosin, doxazosin, or alfuzosin. Taken together with a PDE5 inhibitor these can lower your blood pressure further and cause dizziness or fainting.
Liver or kidney disease, including dialysis. Your dose may need to be adjusted.
Sickle cell anemia, multiple myeloma, leukemia, or a deformity of the penis such as Peyronie's disease, all of which raise the risk of a prolonged erection.
Stomach ulcers or a bleeding disorder, retinitis pigmentosa or other inherited eye disease, or prior sudden vision or hearing loss.
Medications that can raise blood levels of PDE5 inhibitors, including ritonavir and other HIV protease inhibitors, ketoconazole, itraconazole, erythromycin, and clarithromycin. Grapefruit and grapefruit juice can have the same effect.
Any other ED treatment. Do not combine ED medications.

V. Serious Risks

Prolonged erection (priapism). An erection lasting more than 4 hours is a medical emergency and can permanently damage the penis if it is not treated. Seek emergency care immediately.
Sudden vision loss. Sudden loss of vision in one or both eyes can be a sign of non-arteritic anterior ischemic optic neuropathy (NAION), a rare condition reported in men taking PDE5 inhibitors. Stop taking the medication and seek medical care immediately.
Sudden hearing loss. Sudden decrease or loss of hearing, sometimes with ringing in the ears or dizziness, has been reported. Stop taking the medication and seek medical care immediately.
Low blood pressure and fainting. Dizziness, lightheadedness or fainting can occur, particularly when standing up, when combined with alpha-blockers, other blood pressure medication, or alcohol. Apomorphine can also cause nausea, vomiting, sweating, and fainting.
Cardiovascular strain. Sexual activity itself carries risk for men with heart disease. Stop and seek medical attention if you develop chest pain, severe shortness of breath, or an irregular heartbeat during sex.
Allergic reaction. Seek emergency care for rash, hives, swelling of the lips, tongue, or throat, or difficulty breathing.

VI. Common Side Effects

VII. Alcohol and Other Substances

VIII. Reporting Side Effects

Report side effects to your Rodeo Meds care team, and to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

IX. Contact Information

Modern Metabolic Medicine, Inc.
1811 Silverside Road, Suite 260
Wilmington, New Castle County, Delaware 19180
Email: support@mail.withembody.com